Positive Health Online

Abstract

ABDOLAHI and COLLEAGUES, 1 AmirAlam Hospital Complex, Marvasti Hospital, Tehran University of Medical Sciences, Tehran, Iran; 2 Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran; 3 Iranian Centre of Neurological Research, Department of Neurology, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran; 4 Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran; 5 Department of Molecular Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran conducted a study to evaluate the combined effects of ω-3 fatty acids and nano-curcumin supplementation on IL-6 gene expression and serum level and high-sensitivity C-reactive protein (hs-CRP) levels in migraine patients.epub@benthamscience.org.

Background

Migraine is a disabling neuroinflammatory condition characterized by increasing the levels of interleukin (IL)-6, a proinflammatory cytokine and C-reactive protein (CRP) which considered as a vascular inflammatory mediator, disrupting the integrity of blood-brain barrier and contributing to neurogenic inflammation, and disease progression. Curcumin and ω-3 fatty acids can exert neuroprotective effects through modulation of IL-6 gene expression and CRP levels. The aim of present study is the evaluation of combined effects of ω-3 fatty acids and nano-curcumin supplementation on IL-6 gene expression and serum level and hs-CRP levels in migraine patients.

Methodology

Eighty episodic migraine patients enrolled in the trial and were divided into four groups as 1) combination of ω-3 fatty acids (2500 mg) plus nano-curcumin (80 mg), 2) ω-3 (2500 mg), 3) nanocurcumin (80 mg), and 4) the control (ω-3 and nano-curcumin placebo included oral paraffin oil) over a two-month period. At the beginning and the end of the study, the expression of IL-6 from peripheral blood mononuclear cells and IL-6 and hs-CRP serum levels were measured, using a real-time PCR and ELISA methods, respectively.

Results

The results showed that both of ω-3 and nano-curcumin down-regulated IL-6 mRNA and significantly decreased the serum concentration. hs-CRP serum levels significantly decrease in combination and nano-curcumin within groups (P<0.05). An additive greater reduction of IL-6 and hs-CRP was observed in the combination group suggested a possible synergetic relation.

Conclusion

It seems that ω-3 fatty acids and curcumin supplementation can be considered a new promising target in migraine prevention. Trial registration: ClinicalTrials.gov NCT02532023.  Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org .

References

Mina Abdolahi  1   2 , Payam Sarraf  3 , Mohammad Hassan Javanbakht  2 , Niyaz Mohammadzadeh Honarvar  2 , Mahsa Hatami  2 , Neda Soveyd  2 , Abbas Tafakhori  3 , Mohsen Sedighiyan  4 , Mona Djalali  5 , Arash Jafarieh  1 , Yousef Masoudian  1 , Mahmoud Djalali  2. A Novel Combination of ω-3 Fatty Acids and Nano-Curcumin Modulates Interleukin-6 Gene Expression and High Sensitivity C-reactive Protein Serum Levels in Patients with Migraine: A Randomized Clinical Trial Study.  CNS Neurol Disord Drug Targets;17(6):430-438. doi: 10.2174/1871527317666180625101643. 2018.

 

Comment

The above research suggest that ω-3 fatty acids and curcumin supplementation can be considered a new promising target in migraine prevention.