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Research: ALEKEL and colleagues, De
Listed in Issue 60
Abstract
ALEKEL and colleagues, Department of Food Science and Human Nutrition, Human Metabolic Unit, Center for Designing Foods to Improve Nutrition, the Department of Statistics, Iowa State University, Ames 50011-1120, USA. alekel@iastate.edu examined effect of soy protein with isoflavones (80.4 mg/d) on bone or bone turnover in perimenopausal women .
Background
Methodology
Perimenopausal subjects were randomly assigned, double blind, to treatment: isoflavone-rich soy (SPI+ n = 24), isoflavone-poor soy (SPI- n = 24), or whey (control, n = 21) protein for 24 weeks. At baseline and post treatment, lumbar spine bone mineral density (BMD) and bone mineral content (BMC) were measured by using dual-energy X-ray absorptiometry. At baseline, midtreatment, and post treatment, urinary N:-telopeptides and serum bone-specific alkaline phosphatase (BAP) were measured.
Results
The percentage change in lumbar spine BMD and BMC, respectively, did not differ from zero in the SPI+ or SPI- groups, but loss occurred in the control group (-1.28%, -1.73%,). By regression analysis, SPI+ treatment had a positive effect on change in BMD (5.6%) and BMC (10.1%). Baseline BMD and BMC negatively affected the percentage change in their respective models; baseline body weight and bone-free lean weight contributed positively to percentage change in BMD and BMC, respectively. Serum BAP post treatment was negatively related to percentage change in BMD and BMC. Contrast coding using analyses of covariance with BMD or BMC as the outcome showed that isoflavones, not soy protein, exerted the effect .
Conclusion
Soy isoflavones attenuated bone loss from the lumbar spine in perimenopausal women.
References
Alekel DL et al. Isoflavone-rich soy protein isolate attenuates bone loss in the lumbar spine of perimenopausal women. The American Journal of Clinical Nutrition 72(3): 844-52. Sep 2000.
