Positive Health Online

Abstract

AOYAMA and COLLEAGUES,  (1)Dept. of Gastrointestinal Surgery, Kanagawa Cancer Center aimed to evaluate the effects of Prosure® on body weight loss (BWL) and compliance with S-1 adjuvant  chemotherapy after gastrectomy.

Background

Eicosapentaenoic acid-enriched oral nutritional supplements (Prosure®; Abbott Japan, Tokyo, Japan) may attenuate surgical stress and catabolism after gastric cancer surgery. The present study aimed to evaluate the effects of Prosure® on body weight loss (BWL) and compliance with S-1 adjuvant chemotherapy after gastrectomy.

Methodology

Patients who underwent curative total gastrectomy for gastric cancer were selected to undergo adjuvant S-1 chemotherapy at Kanagawa Cancer Center between December 2010 and October 2011. The patients received a normal post-gastrectomy diet and two 240 mL packs of Prosure® for 21 postoperative days. BWL was defined as %BWL and calculated as %BWL=(preoperative body weight-1-month postoperative body weight) × 100/preoperative body weight. Time to S-1 treatment failure was calculated.

Results

Five patients were enrolled in this study. The median age was 62.0 years. One patient was male, and 4 were female. The 1-month postoperative BWL was 92.1%. Compared to our previous report, a 20% risk reduction was observed in this study (Prosure® group vs control group, 92.1% vs 89.7%). Moreover, all the patients continued with the S-1 adjuvant chemotherapy for longer than 6 months.

Conclusion

Prosure® may inhibit BWL at 1 month after gastrectomy. Moreover, Prosure® improved the patients' compliance with the adjuvant chemotherapy after gastrectomy.

References

Aoyama T(1), Hayashi T, Fujikawa H, Ogata T, Cho H, Wada H, Kitani Y, Yukawa N,  Oshima T, Rino Y, Ozawa Y, Masuda M, Yoshikawa T.  [Effect of enteral nutrition enriched with eicosapentaenoic acid on body weight  loss and compliance with S-1 adjuvant chemotherapy after gastric cancer surgery]. [Article in Japanese] Gan To Kagaku Ryoho 40(12): 2289-91. Nov 2013.