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Research: Basu and colleagues, D
Listed in Issue 62
Abstract
Basu and colleagues, Department of Pharmaceutical Technology, Jadavpur University, Calcutta, India. examined the effect of beta-carotene in transplantable murine lymphoma .
Background
Dietary carotenoids have been the subject of renewed research interest because of epidemiological evidence indicating an inverse relationship between intake of carotenoids-rich plant substances and risk of certain cancers . This study examined the biological actions of dietary beta-carotene (BC) on Dalton's lymphoma (DL), a rapidly proliferating transplantable tumour, in lymphoma-bearing mice.
Methodology
The glutathione (GSH) level and the extent of lipid peroxidation in the liver, kidney and brain were monitored in BC-treated (100 mg/kg food) mice transplanted with DL. These markers showed substantial alterations during the whole length of tumour progression in lymphoma-bearing mice without BC supplementation.
Results
When treated with BC, both malondialdehyde contents (evidence of lipid peroxidation) and the GSH levels in different organs were found to be closer to normal values in the initial period of tumour progression. BC-mediated protection against lipid peroxidation was maximally found to be in hepatic tissue throughout the study following DL transplantation. This was fairly reflected in the higher BC concentration in hepatic tissue of BC-treated lymphoma group compared to untreated lymphoma control. Significantly higher survival time (51-55 days) was observed in BC-treated animals in comparison to their untreated DL counterparts (35-38 days).
Conclusion
The authors concluded that the prolonged survival observed in the Beta Carotene-supplemented animals may be attributed to the higher resistance offered by animals receiving Beta Carotene towards lipid peroxidation-related tissue injury .
References
Basu M et al. Beta-carotene prolongs survival, decreases lipid peroxidation and enhances glutathione status in transplantable murine lymphoma. Phytomedicine 7(2): 151-9. Apr 2000.
