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Research: CARR and co-authors,
Listed in Issue 127
Abstract
CARR and co-authors, Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9032, USA, have investigated the relationship between vitamin E supplementation, HRT, and markers of cardiovascular inflammation.
Background
The aim of the study was to investigate the effect of vitamin E with and without oestrogen replacement therapy (HRT) on inflammatory markers in postmenopausal women.
Methodology
In this prospective, randomized, double-blind study, 75 postmenopausal healthy women were enrolled. All women were studied at baseline and received vitamin E for 4 weeks. They were then randomized from week 4 to week 12 to receive vitamin E in conjunction with oestrogen, oestrogen plus medroxyprogesterone acetate, or placebo. Change from baseline and between groups in seven circulatory inflammatory markers were the main outcome measures.
Results
Vitamin E levels increased to a similar extent in all three groups compared with baseline at weeks 4 and 12. Vitamin E increased serum interleukin-6 levels. Combination HRT significantly increased C-reactive protein levels. However, there were no consistent statistically significant effects on six other inflammatory markers.
Conclusion
It can be concluded that vitamin E and HRT do not play a major role in promoting a change in cardiovascular inflammatory markers.
References
Carr BR, Khan N, Adams,Huet B, Kakarla N, Havelock JC, Gell J. Effect of vitamin E supplementation with and without hormone therapy on circulatory inflammatory markers in postmenopausal women. Fertility & Sterility 85 (3): 667-673, Mar 2006.
