Positive Health Online
Your Country
![[Image: http://www.abundanceandhealth.co.uk]](/img/original/BannerAvatar/2836.df7d2315253110ff5b3a566f94871f99.jpg "http://www.abundanceandhealth.co.uk")
![[Image: https://www.water-for-health.co.uk/]](/img/original/BannerAvatar/4046.12831f50177f8848ee87b8e94411d6b3.jpg "https://www.water-for-health.co.uk/")
![[Image: http://www.balens.co.uk]](/img/original/BannerAvatar/2148.50367fa908013fae0a7f1a171543ef92.jpg "http://www.balens.co.uk")
![[Image: http://www.drsgoodman.com/books-goodman/52-nutrition-and-cancer]](/img/original/BannerAvatar/1859.1296090fd8385e7ceff51c8011559097.jpg "http://www.drsgoodman.com/books-goodman/52-nutrition-and-cancer")
Research: CHEN and COLLEAGUES,
Listed in Issue 256
Abstract
CHEN and COLLEAGUES, 1. Department of Medical Genetics, China Medical University, Shenyang, 110122, P.R. China; 2. Department of Laboratory Medicine, No. 202 Hospital of PLA, Shenyang, 110003, P.R. China; 3. Department of Otolaryngology, No. 463 Hospital of PLA, Shenyang, 110007, P.R. China explored the role and molecular mechanism of miR-27a in laryngeal cancer differentiation.
Background
miR-27a regulates cell differentiation in a variety of diseases. However, whether and how miR-27a participates in laryngeal cancer cell differentiation remains unknown.
Methodology
The authors explored the role and molecular mechanism of miR-27a in laryngeal cancer differentiation in the study.
Results
The authors found that miR-27a expression was inversely correlated with laryngeal cancer differentiation degree based on the clinical pathological diagnosis of each patient. miR-27 significantly rescued differentiation and inhibited β-catenin, LEF1, OCT4 and SOX2 in Wnt/β-catenin pathway in all-trans-retinoic acid (ATRA)-induced laryngeal cancer cells. Bindings of RARα to miR-27a and miR-27a to GSK-3β were confirmed by ChIP and Luciferase reporter assays, respectively.
Conclusion
In conclusion, miR-27a is a negative regulator in laryngeal cancer differentiation. RARα-mediated miR-27a transcriptional inactivation releases the inhibition of miR-27a on GSK-3β leading to laryngeal cancer differentiation through GSK-3β-involved Wnt/β-catenin pathway, suggesting that miR-27a is a usefully therapeutic target at least in ATRA-induced laryngeal cancer differentiation.
References
Chen S1, Sun YY1, Zhang ZX1, Li YH2, Xu ZM3, Fu WN1. Transcriptional suppression of microRNA-27a contributes to laryngeal cancer differentiation via GSK-3β-involved Wnt/β-catenin pathway. Oncotarget. 8(9):14708-14718. doi: 10.18632/oncotarget.14769. Feb 28 2017.
Comment
The above research emanating from Shenyang, P.R China describes the negative regulation by miR-27a of laryngeal cancer differentiation which suggests the possibility of this being used therapeutically in laryngeal cancer. The complexities of gene regulation at the molecular level of cancer research!
