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Research: CHEN and HUANG.
Listed in Issue 292
Abstract
CHEN and HUANG. 1 Active Carbohydrate Research Center, College of Chemistry, Chongqing Normal University, Chongqing, 401331, China; 2 Active Carbohydrate Research Center, College of Chemistry, Chongqing Normal University, Chongqing, 401331, China. huangdoctor226@163.com analyzed and discussed chemical modification of polysaccharides and the immunomodulation of polysaccharides and polysaccharide derivatives.
Background
Polysaccharide is a kind of natural macromolecule polymer, which is widely existed in animals, plants and microorganisms, has a variety of biological activities, such as anti-tumor, anti-virus, anti-oxidation and immune regulation.
Methodology
Polysaccharides can affect macrophages, cells and other immune cells to improve the body's immune function, and have no toxic and side effects on normal cells, which make the polysaccharides receive widespread attention.
Results
In recent years, studies have shown that structural modification of polysaccharides can improve the immunological activity of polysaccharides. The common chemical modifications are sulfation, carboxymethylation, acetylation, phosphorylation, and so on.
Conclusion
The chemical modification of polysaccharides and the immunomodulation of polysaccharides and polysaccharide derivatives were analyzed and discussed. Copyright © 2018 Elsevier
References
B.V. Fang Chen 1 , Gangliang Huang 2 Preparation and immunological activity of polysaccharides and their derivatives Int J Biol Macromol.; 112:211-216. doi: 10.1016/j.ijbiomac.2018.01.169. Epub Jan 31 2018. Jun 2018.
