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Research: CHEN and others,
Listed in Issue 140
Abstract
CHEN and others, Department of Nutrition and Health Sciences, Taipei Medical University, Taipei, Taiwan, have studied the effects of soya protein on the fat profile of people with elevated cholesterol.
Background
Clinical trials have shown that soya protein reduces the concentrations of some atherogenic lipids in subjects with normal renal function. The aim of this study was to examine the effects of soya protein on serum lipid concentrations and lipoprotein metabolism in hypercholesterolaemic patients on haemodialysis.
Methodology
26 high-cholesterol patients on haemodialysis were studied in a randomized, double-blind, placebo-controlled clinical trial. After a 4-week run-in phase, the subjects were randomly assigned to two groups. Isolated soya protein or milk protein 30 g was consumed daily as a beverage at breakfast for 12 weeks.
Results
Soya protein substitution resulted in significant reductions in total cholesterol (17.2%), LDL-cholesterol (15.3%), apo B (14.6%) and insulin (23.8%) concentrations. There were no significant changes in HDL-cholesterol or apo A-I.
Conclusion
These results indicate that replacing part of the daily protein intake with soya protein has a beneficial effect on atherogenic lipids and may reduce the risk of cardiovascular disease.
References
Chen ST, Chen JR, Yang CS, Peng SJ, Ferng SH. Effect of soya protein on serum lipid profile and lipoprotein concentrations in patients undergoing hypercholesterolaemic haemodialysis. British Journal of Nutrition 95 (2): 366-371, Feb 2006.
