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Research: DATTA and colleagues,
Listed in Issue 48
Abstract
DATTA and colleagues, Kalyani University, Department of Zoology, India compared, in mice, the efficacy of Arsenicum Album 30C and 200C in protecting against genotoxic effects produced by Arsenic trioxide (As203) injection.
Background
Methodology
Healthy mice were injected intraperitoneally with a 0.004% solution of As203 (1 ml/100 gm body weight). Genotoxic effects were assessed through chromosome aberrations (CA), micronucleated erythrocytes (MNE) mitotic index (MI) and sperm head anomaly (SHA) studies. The authors maintained both positive (succussed alcohol-fed) and untreated negative controls. The As203 treated mice were divided into 3 subgroups, which were orally administered the drug 1) prior to; b) following and c)both prior to and following injection of As203 at specific intervals.
Results
Compared to respective controls, CA, MNE and SHA were reduced in the drug-fed series, and MI showed an apparent increase. The most effective in reducing the genotoxic effects of As203 was the combined pre- and post-feeding of Arsenicum album i200C, which was more effective than 30C.
Conclusion
Arsenicum album reduces the genotoxic effect of arsenic poisoning.
References
Datta S et al. Efficacy of a potentized homoeopathic drug (Arsenicum Album-30) in reducing genotoxic effects produced by arsenic trioxide in mice: comparative studies of pre-, post- and combined pre- and post-oral administration and comparative efficacy of two microdoses. Complementary Therapies in Medicine. 7(2): 62-75. Jun 1999.
