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Research: Department of Oncology,
Listed in Issue 92
Abstract
Department of Oncology, University of Leicester, Leicester LE2 7LX, UK, have reviewed (95 references) the chemoprevention of prostate cancer by antioxidant agents in the diet and hormonal manipulation. Abstract: Prostate cancer is the most commonly diagnosed solid cancer and the second leading cause of cancer-related death in men in the Western world. There is an increased need to prevent the onset of this cancer, and to delay or reverse carcinogenesis. An example is the reversal of neoplasia by hormonal manipulation using anti-oestrogens in breast cancer or anti-androgens in prostate cancer. Epidemiological data suggest that dietary intake of antioxidants may be protective. These agents include vitamins D and E, soy, lycopene, and selenium. 5-alpha reductase inhibitors may also constitute a potential chemoprevention. The efficacy of chemopreventive agents needs to be ascertained in randomized, placebo-controlled clinical trials of suitable groups of high-risk individuals. In addition, reliable assays of potential biomarkers of the efficacy of an intervention need to be developed.
Background
Methodology
Results
Conclusion
References
Pathak SK, Sharma RA, Mellon JK. Chemoprevention of prostate cancer by diet-derived antioxidant agents and hormonal manipulation (Review). International Journal of Oncology 22 (1): 5-13, Jan 2003.
