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Research: DIXON-SHANIES and SHAI
Listed in Issue 51
Abstract
DIXON-SHANIES and SHAIKH, The New York College of Osteopathic Medicine of the New York Institute of Technology, Old Westbury, NY 11568-8000 USA write that epidemiological research has suggested that phytoestrogen-rich foods may afford protection against breast cancer and that phytoestrogens including genistein have been reported to both inhibit and stimulate human breast cancer cell growth .
Background
Methodology
The authors tested the phytoestrogens genistein, daidzein, biochanin A and coumestrol .
Results
Genistein, daidzein, biochanin A and coumestrol inhibited serum-stimulated growth in T-47D and MCF-7 breast cancer cells at concentrations of 10-100 microM. Furthermore, extracts of the oestrogenic herbs, including hops, black cohosh and vitex inhibited the growth of T-47D cells.
Conclusion
The results of these in vitro tests suggest that various herbs and phytoestrogens may potentially have a role in the prevention of breast cancer in humans .
References
Dixon-Shanies D and Shaikh N. Growth inhibition of human breast cancer cells by herbs and phytoestrogens. Oncology Reports 6(6): 1383-7. Nov-Dec 1999.
