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Research: DUDEK and colleagues,
Listed in Issue 106
Abstract
DUDEK and colleagues, Department of Neurosurgery, Medical University of Bialystok have investigated the activity of antioxidant enzymes in human brain tumours.
Background
The aim of the study was to assess the activity of a range of antioxidant enzymes and the concentration of antioxidants in brain tumours of various levels of malignancy.
Methodology
105 samples of brain tumours were obtained from patients undergoing surgery over five years. The values of enzyme activities and the concentrations of antioxidant substances obtained were compared to values from 15 samples of histologically unchanged brain tissue.
Results
The increase in all antioxidant enzyme activities in tumours is statistically significant. A significant decrease was found in the levels of reduced glutathione and vitamin C, and an increase in substance reactive to thiobarbituric acdid.
Conclusion
Brain tumours show increased levels of activity of all enzymes metabolizing antioxidants, and lower levels of antioxidant substances.
References
Dudek H, Farbiszewski R, Rydzewska M, Michno T, Kozlowski A. Evaluation of antioxidant enzymes activity and concentration of non-enzymatic antioxidants in human brain tumours. Wiadomosci Lekarkie 57 (1-2): 16-19, 2004.
