Positive Health Online

Abstract

EFTEKHARSADAT and COLLEAGUES, 1 Physical Medicine and Rehabilitation Research Center, Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran; 2 Department of Anesthesiology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran; 3 Department of Biology, School of Art and Science, Utica College, Utica, NY, United States;    4 Faculty of Medicine, Islamic Azad University, Tabriz, Iran aimed to determine dietary intake and serum concentration of α-tocopherol and lycopene in subjects with knee osteoarthritis (KOA) in relation to pain intensity and functional status and comparing them with healthy controls.

Background

The authors aimed to determine dietary intake and serum concentration of α-tocopherol and lycopene in subjects with knee osteoarthritis (KOA) in relation to pain intensity and functional status and comparing them with healthy controls.

Methodology

This case-control study was conducted among 35 patients with primary KOA and 35 matched healthy subjects selected using convenience sampling method. Dietary intakes of alpha-tocopherol and lycopene were estimated from 24-hour dietary records. Visual Analogue Scale (VAS) and Western Ontario and McMaster (WOMAC) index were used to assess the pain and functional status, respectively.

Results

Serum concentrations of alpha-tocopherol (0.024 ± 0.005 vs. 0.028 ± 0.007 μmol/ml, p-value = 0.021) and lycopene (0.616 ± 0.191 vs. 0.727 ± 0.159 μmol/l, p-value = 0.011) were significantly lower in OA patients in comparison with healthy controls. Dietary intake of alpha-tocopherol was negatively associated with total WOMAC score (r = -0.401, p-value = 0.021) and pain (r = -0.356, p-value = 0.042) and physical function (r = -0.355, p-value = 0.043) subscales. Dietary intake of lycopene was negatively associated with total WOMAC score (r = -0.616, p-value < 0.001) and pain (r = -0.348, p-value = 0.047) and physical function (r = -0.606, p-value < 0.001) subscales. Additionally, serum concentration of alpha-tocopherol was negatively associated with total WOMAC score (r = -0.574, p-value < 0.001) and physical function subscale (r = -0.571, p-value < 0.001). Serum concentration of lycopene was negatively associated with total WOMAC score (r = -0.360, p-value = 0.040) and physical function subscale (r = -0.350, p-value = 0.046)

Conclusion

Serum concentrations of α-tocopherol and lycopene were significantly lower in patients with knee osteoarthritis (KOA) than in healthy controls. Significant negative association was detected between serum concentration and dietary intake of α-tocopherol and lycopene with functional disability in patients with KOA.

References

Bina Eftekharsadat  1 , Dawood Aghamohammadi  2 , Neda Dolatkhah  1 , Maryam Hashemian  3 , Halale Salami  4. Lower serum levels of alpha tocopherol and lycopene are associated with higher pain and physical disability in subjects with primary knee osteoarthritis: A case-control study Int J Vitam Nutr Res.; 91(3-4):304-314. doi: 10.1024/0300-9831/a000635. https://pubmed.ncbi.nlm.nih.gov/31971481/ Epub Jan 23 2020 . Jun 2021.