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Research: FOSTER et al, O
Listed in Issue 83
Abstract
FOSTER et al, Office of Science, Therapeutic products Directorate, Health Canada, Ottawa, Ontario, Canada; Centre for Research in Biopharmaceuticals, University of Ottawa, Ontario K1A 1B6, Canada, E: brian_foster@hc-sc.gc.ca investigated the effect of several Chinese natural health products upon cytochrome P-450 metabolism .
Background
Certain traditional Chinese medicines have been associated with adverse reactions in which cytochrome P-450 was thought to be involved.
Methodology
In vitro assay of cytochrome P-450 metabolizing enzymes 2C9, 2C19, 2D6, and 3A4 in the presence of 12 different traditional Chinese medicines, directly or as extracts.
Results
Most extracts of traditional Chinese medicines inhibited between 25 to 100%.of the activity of the enzymes tested .
Conclusion
Cytochrome P-450 metabolism can be affected by traditional Chinese medicines in vitro, and this effect needs to be further investigated in order to assess the safety and efficacy of conventional therapeutic products.
References
Foster BC, Vandenhoek S, Tang R, Budzinaki JW, Krantis A, Li KY. Effect of several Chinese natural health products of human cytochrome P450 metabolism. Journal of Pharmacy and Pharmaceutical Sciences 5 (2): 185-189, Aug 2002.
