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Research: FUJIKI and colleagues,
Listed in Issue 90
Abstract
FUJIKI and colleagues, Department of Biochemistry, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-Cho, Tokushima 770-8514, Japan, hfujiki@ph.bunri-u.ac.jp, reported on new cancer preventive agents from traditional herbal medicine.
Background
Herbal medicines are increasingly attracting attention as cancer preventive agents. This study identifies and describes two new agents, geraniin and corilagin.
Methodology
The cancer preventive effects of various extracts of plants used in traditional herbal medicine were tested in several experiments using cells in culture.
Results
A leaf extract from Acer nikoense was found to inhibit tumour necrosis factor-alpha secretion. The active principles were geraniin and corilagin. The effective concentrations were in the same range as that of the active principle from green tea (EGCG) which has been known to act as a cancer preventive for some time. Geraniin was found to prevent the formation of skin tumours. The authors further review recent results from studies with EGCG which has been found to be particularly effective in combination with the cancer preventive drugs tamoxifen and sulindac.
Conclusion
The authors urge strongly that the potential of traditional herbal medicines be investigated more closely for their cancer preventive effects.
References
Fujiki H, Suganuma M, Kurusu M, Okabe S, Imayoshi Y, Taniguchi S, Yoshida T. New TNF-alpha releasing inhibitors as cancer preventive agents from traditional herbal medicine and combination cancer prevention study with EGCG and sulindac or tamoxifen. Mutation Research 523-524: 119-125, Feb-Mar 2003.
