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Research: GHALAUT, SINGH and GUP
Listed in Issue 57
Abstract
GHALAUT, SINGH and GUPTA, Dept of Medicine (Unit-VI) and Haematology, Pt BD Sharma Post Graduate Institute of Medical Sciences, Rohtak set out to investigate Serum vitamin E levels in patients of chronic myeloid leukaemia.
Background
To estimate vitamin E levels in sera of patients of chronic myeloid leukaemia (CML) before and after treatment with busulphan and hydroxyurea and to compare the levels with those in healthy controls.
Methodology
The study of 50 subjects (mean age 34 ±8.86 years), 25 of which were proved cases of chronic myeloid leukaemia (CML) and 25 were healthy controls. Vitamin E level was measured by spectrofluorometric method. In patients of CML, vitamin E level was estimated twice. Once when their total leucocyte count (TLC) was raised (i.e. before treatment) and then after treatment after bringing the TLC near normal.
Results
The mean serum vitamin E level in 25 normal healthy controls was 7.19 mcg/ml and that in 25 patients of CML at presentation (before treatment) was 2.67 mcg/ml. It increased to 3.61 mcg/ml after treatment.
Conclusion
The results show that patients of CML have a significantly lower (p < 0.001) level of serum vitamin E as compared to normal healthy adults and that the level of vitamin E increased significantly (p < 0.001) after treatment even without supplementing vitamin E.
References
Ghalaut PS et al. Serum vitamin E levels in patients of chronic myeloid leukaemia. Journal of Association of Physicians of India 47(7): 703-4. Jul 1999.
