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Research: GHAYUR and GILANI,
Listed in Issue 119
Abstract
GHAYUR and GILANI, Department of Biological and Biomedical Sciences, The Aga Khan University Medical College, Karachi, Pakistan, have elucidated the mechanism by which ginger lowers blood pressure.
Background
Ginger (Zingiber officinale) has been used traditionally in a wide variety of ailments including hypertension. The aim of this study was to investigate the cardiovascular effects of ginger under controlled experimental conditions.
Methodology
Animal study using anaesthetixed rats, guinea pigs and rabbits.
Results
Crude ginger extract induced a dose-dependent fall in arterial blood pressure. It acts as a cardiodepressant, and the force and rate of heartbeat are lowered. It also exhibits the action of a vasodilator. Its activity on calcium-channels resembled that of the drug verapamil.
Conclusion
These data indicate that the blood pressure-lowering effect of ginger is mediated by blocking voltage-dependent calcium channels.
References
Ghayur MN, Gilani AH. Ginger lowers blood pressure through blockade of voltage-dependent calcium channels. Journal of Cardiovascular Pharmacology 45 (1): 74-80, Jan 2005.
