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Research: GHOSE and colleagues,
Listed in Issue 73
Abstract
GHOSE and colleagues, CRC Beatson Laboratories, The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow, G61 1BD, UK, reviewed (35 references) research on the possible mechanism(s) of selenium's chemopreventive effects .
Background
Accumulated evidence from prospective studies, intervention trials and studies on animal models of cancer has suggested a strong inverse correlation between selenium (Se) intake and cancer incidence . Several putative mechanisms have been suggested to mediate the chemopreventive activities of Se. Of these, the inhibition of cellular proliferation and the induction of apoptosis are particularly attractive.
Methodology
Results
Conclusion
References
Ghose A et al. Selenium and signal transduction: roads to cell death and anti-tumour activity. BioFactors 14 (1-4): 127-33. 2001.
