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Research: GREYBELS and COLLEAGUES,
Listed in Issue 223
Abstract
GREYBELS and COLLEAGUES, investigated whether the association between toenail selenium levels and advanced PCa risk in the prospective Netherlands Cohort Study is modified by common genetic variation in SEPP1 and GPX1.
(1)Affiliations of authors: Department of Epidemiology (MSG, PvdB, LS, BV) and Department of Toxicogenomics (SvB), GROW School for Oncology and Developmental Biology, and Department of Toxicology (FvS), NUTRIM School for Nutrition, Toxicology, and Metabolism, Maastricht University, Maastricht, the Netherlands; Department of Nutritional Sciences (MR) and Department of Biochemistry and Physiology (FG), Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK.
Background
Lower selenium levels have been associated with increased risk of prostate cancer (PCa), and genetic variation in the selenoprotein genes selenoprotein P (SEPP1) and glutathione peroxidase 1 (GPX1) is thought to modify this relationship.
Methodology
The authors investigated whether the association between toenail selenium levels and advanced PCa risk in the prospective Netherlands Cohort Study is modified by common genetic variation in SEPP1 and GPX1. Toenail clippings were used to determine selenium levels and to isolate DNA for genotyping. This case-cohort study, which included 817 case subjects with advanced PCa and 1048 subcohort members, was analyzed with Cox regression models. All statistical tests were two-sided.
Results
Three genetic variants were associated with advanced (stage III/IV or IV) PCa risk: SEPP1 rs7579 (lower risk; P trend = .01), GPX1 rs17650792 (higher risk; P trend = .03), and GPX1 rs1800668 (lower risk; P trend = .005).
Conclusion
Toenail selenium levels were inversely associated with advanced PCa risk, independently of common genetic variation in SEPP1 and GPX1.
References
Geybels MS(1), van den Brandt PA, Schouten LJ, van Schooten FJ, van Breda SG, Rayman MP, Green FR, Verhage BA. Selenoprotein gene variants, toenail selenium levels, and risk for advanced prostate cancer. J Natl Cancer Inst. 106(3):dju003. doi: 10.1093/jnci/dju003. Mar 2014. Epub Feb 22 2014. Comment in Nat Rev Urol. 11(4):184. Apr 2014.
