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Research: GUNN and COLLEAGUES,
Listed in Issue 195
Abstract
GUNN and COLLEAGUES, Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA tested the anti-multiple myeloma cancer stem cell (MM-CSC) potential of two natural product inhibitors of nuclear factor kappaB (NFkappaB).
Background
Multiple myeloma (MM) is an incurable plasma cell malignancy where nearly all patients succumb to a relapse. The current preclinical models of MM target the plasma cells, constituting the bulk of the tumour, leaving the cancer stem cells to trigger a relapse.
Methodology
Utilizing a three-dimensional tissue culture system where cells were grown in extracellular matrix designed to reconstruct human bone marrow, we tested the anti-multiple myeloma cancer stem cell (MM-CSC) potential of two natural product inhibitors of nuclear factor kappaB (NFkappaB).
Results
Here the authors show that parthenolide and andrographolide are potent anti-MM-CSC agents. Both natural products demonstrated preferential toxicity toward MM-CSCs over non-tumorigenic MM cells. Addition of the bone marrow stromal compartment abrogated andrographolide activity while having no effect on parthenolide cytoxicity.
Conclusion
This is the first report of a natural product with anti-CSC activity in myeloma, suggesting that it has the potential to improve the survival of patients with MM by eliminating the relapse-causing MM-CSCs.
References
Gunn EJ, Williams JT. Huynh DT, Iannotti MJ. Han C, Barrios FJ. Kendall S, Glackin CA. Colby DA and Kirshner J. The natural products parthenolide [A sesquiterpene lactone which occurs naturally in the plant feverfew (Tanacetum parthenium); used for the relief of migraine] and andrographolide [a genus of Indian plants (family Acanthaceae) with entire leaves, small tubular flowers. Andrographis paniculata, found in Asia and India has been used in traditional Chinese and Indian medicine to treat a variety of viral infections and has been found to have an inhibitory effect on HIV] exhibit anti-cancer stem cell activity in multiple myeloma. Source Leukemia & Lymphoma. 52(6):1085-97. Jun 2011.
