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Research: HAIDARI and colleagues,
Listed in Issue 78
Abstract
HAIDARI and colleagues, Cardiovascular Research Center, Tehran University of Medical Sciences, Tehran, Iran, mhaidari@sickkids.on.ca, investigated whether enhanced susceptibility of low-density lipoprotein (LDL) to oxidation and decreased vitamin E concentration in LDL were additional risk factors for atherosclerosis in Iranian patients with established coronary artery disease (CAD).
Background
Evidence indicates that oxidative modification of LDL is an important trigger in a complex chain of events leading to atherosclerosis.
Methodology
132 Iranian patients with angiographically confirmed CAD were examined and compared with 111 healthy Iranian control subjects. Susceptibility of LDL to copper-mediated oxidation was assessed by measuring conjugated diene production. Vitamin E content of LDL was measured by high-pressure liquid chromatography (HPLC).
Results
The mean lag time of LDL oxidation and LDL alpha-tocopherol/ LDL-cholesterol ratio were lower in patients with CAD than in controls (5514 min and 2.41.0 mmol/mmol, compared with 6313 min and 2.91.1 mmol/mmol; p<0.0001 and p<0.001, respectively). Multiple stepwise regression analysis showed the lag time (OR 1.96; 95% CI 1.34, 2.87; p<0.0001) and concentration of vitamin E in LDL (OR 1.65; 95% CI 1.16, 2.33; p<0.005) to be independent determinants of CAD. Significant inverse Spearman rank correlations were found between lag time (r=-0.285; p<0.001) or concentration of vitamin E in LDL (r=-0.197; p<0.002) and severity of CAD. Lag times were not significantly correlated with serum C-reactive protein or ferritin.
Conclusion
These data suggest that a short LDL oxidation lag time and a low concentration of vitamin E in LDL might be independent coronary risk factors for stable CAD in Iranian people.
References
Haidari M et al. Enhanced susceptibility to oxidation and diminished vitamin E content of LDL from patients with stable coronary artery disease. Clinical Chemistry 47 (7): 1234-40. 2001.
Comment
Both the above research studies demonstrate important associations between nutrients – lycopene and vitamin E – and risks of coronary heart disease and stroke. @i:68
