Research: HARRISON and ABHYANKAR,

Listed in Issue 117

Abstract

HARRISON and ABHYANKAR, Noble's Hospital, Isle of Man, UK, have reviewed (59 references) the mechanism of action of n-3 fatty acids in the prevention of myocardial infarction.

Background

n-3 fatty acids from oily fish have a protective effect against heart disease. The aim of this study was to outline the mechanisms through which n-3 fatty acids might confer cardiac benefits over and above the standard secondary prevention strategies.

Methodology

Results

The conclusion reached is that n-3 fatty acids play a significant role in secondary prevention post-myocardial infarction. The mechanisms through which two of these omega-3 fatty acids, eicosapentaenoic acid and docosahexaenoic acid, exert their action appear to be distinct and adjuvant to the available standard secondary prevention therapies. The role to be played by a newly licensed 90% concentrate EPA + DHA formulation (1 g/day capsule: Omacor) is explored.

Conclusion

References

Harrison N, Abhyankar B. The mechanism of action of omega-3 fatty acids in secondary prevention post-myocardial infarction. Current Medical Research & Opinion 21 (1): 95-100, Jan 2005.

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