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Research: HE and co-authors,
Listed in Issue 146
Abstract
HE and co-authors, Institute of Occupational Medicine and the Ministry of Education Key Lab of Environment and Health, Wuhan, Hubei, China, have studied a genetic risk factor for heart disease and its association with smoking and vitamin E.
Background
The C242T polymorphisms of P22(phox) gene and plasma vitamin E have been associated with the risk of coronary heart disease in several studies, but the results have been inconsistent. The aim of this study was to examine potential interactions between P22(phox) genotypes, plasma vitamin E concentrations, and smoking in relation to coronary heart disease risk.
Methodology
The C242T genotype frequency in the P22(phox) gene and plasma levels of vitamin E were determined in 565 Chinese patients with coronary heart disease and 609 control subjects. Logistic regression was used to control for potential confounders in multivariate analyses.
Results
Compared with subjects with a CC genotype, subjects with a CT or TT genotype had a lower risk of coronary heart disease (odds ratio 0.45, p = 0.001). Plasma concentrations of vitamin E were lower in case patients than in control subjects (odds ratio 0.65, p = 0.025). Compared with nonsmokers with a CC genotype, nonsmokers with a CT or TT genotype had a decreased risk of coronary heart disease (odds ratio 0.25), but smokers with a CT or TT genotype had an increased risk (odds ratio 2.04, p for interaction = .039). Smokers with a lower vitamin E concentration had a >3.0-fold greater risk of coronary heart disease than did nonsmokers with a higher vitamin E concentration (odds ratio 3.52, p for interaction = .041).
Conclusion
These data provide evidence that P22(phox) genotypes are significantly associated with coronary heart disease risk in a Chinese population and suggest potential interactions among smoking, P22(phox) genotypes, and vitamin E in relation to coronary heart disease risk.
References
He MA et al. Associations of polymorphism of P22(phox) C242T, plasma levels of vitamin E, and smoking with coronary heart disease in China. American Heart Journal 153 (4): 640.e1-640.e6, Apr 2007.
