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Research: HEMILA and colleagues,
Listed in Issue 50
Abstract
HEMILA and colleagues, Department of Public Health, University of Helsinki, Finland studied the association of vitamin C intake and risk of tuberculosis .
Background
Methodology
The authors analysed 167 incident cases of tuberculosis during a median follow-up time of 6.7 years within a clinical trial cohort of 26,975 Finnish men for whom baseline dietary data were on record.
Results
The study demonstrated a highly statistically significant inverse association between calculated vitamin C intake and tuberculosis incidence; however following adjustment for non-dietary factors, the association weakened to nonsignificant. Additionally, risk of tuberculosis decreased with increasing intake of fruits, vegetables and berries independent of vitamin C intake. Individuals with dietary vitamin C intake >90 mg per day and who consumed more than the average amount of fruits, vegetables, and berries had a significantly lower risk of tuberculosis (adjusted relative risk (RR) = 0.40).
Conclusion
Lower tuberculosis incidence in people who consume more fruits, vegetables and berries poor in vitamin C suggests that other compounds apart from vitamin C in such a diet may reduce the risk of tuberculosis .
References
Hemila H et al. Vitamin C and other compounds in vitamin C rich food in relation to risk of tuberculosis in male smokers. American Journal of Epidemiology 150(6): 632-41. 15 Sep 1999.
