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Research: JAGTAP and colleagues,
Listed in Issue 101
Abstract
JAGTAP and colleagues, Department of Pharmacology, Bombay College of Pharmacy, Kalina, Santacruz (E), Mumbai 400 098, India, have tested the effects of a herbal medicine on animal models of inflammatory bowel disease.
Background
The aim of the study was to re-validate the efficacy of an ancient Ayurvedic herbal formulation found to be beneficial in clinical practice for inflammatory bowel disease (ulcerative colitis) in experimental models.
Methodology
An aqueous extract of four herbs was used: Bilwa (Aegle marmeloes), Dhanyak (Coriandrum sativum), Musta (Cyperus rotundus), and Vala (Vetiveria zinzanioids). The medicine was tested on acetic acid-induced colitis in mice, and on indomethacin-induced enterocolitis in rats. Prednisolone was used as a control treatment.
Results
The herbal medicine showed significant activity against these two experimental models of inflammatory bowel disease. The activity was comparable to the activity of the control agent.
Conclusion
These results confirm the efficacy of this ancient Ayurvedic herbal formulation as a treatment for inflammatory bowel disease.
References
Jagtap AG, Shirke SS, Phadke AS. Effect of polyherbal formulation on experimental models of inflammatory bowel disease. Journal of Ethnopharmacology 90 (2-3): 195-204, Feb 2004.
