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Research: JAMISON and colleagues,
Listed in Issue 82
Abstract
JAMISON and colleagues, Department of Urology, Summa Health System/Northeastern Ohio Universities College of Medicine, 2209 State Route 44, P. O. Box 95, Rootstown, Ohio 44272-0095, USA, jmj@neoucom.edu, reviewed (68 references) the antitumour activity of Vitamins C and K3 by preferential killing of tumour cells by autoschizis, a novel type of necrosis .
Background
Vitamin C and Vitamin K3, administered at a ratio of 100: 1, show synergistic antitumour activity and preferentially kill tumour cells by autochizis. This type of cell death is characterized by exaggerated membrane damage and progressive loss of cytoplasm. The cell nucleus becomes smaller, cell size decreases, and most organelles surround the nucleus in a narrow band of cytoplasm. There appears to be a G1/S block in the cell cycle, diminished DNA synthesis, and increased hydrogen peroxide levels.
Methodology
Results
Conclusion
References
Jamison JM et al. Autoschizis: a novel cell death. Biochemical Pharmacology 63 (10): 1773-83. May 2002.
