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Research: JAMISON and colleagues,
Listed in Issue 113
Abstract
JAMISON and colleagues, Department of Urology, College of Medicine, Northeastern Ohio Universities, Summa Health System/NEOUCOM, Akron, OH 44304, USA, jmj@neoucom.edu, have treated a human bladder carcinoma cell line with vitamins C and K3.
Background
The aim of the study was to characterize the effects of vitamins C and K3 on human bladder tumour cells.
Methodology
Human bladder tumour cells in culture were treated with vitamin C, vitamin K3, or a combination of both for several hours. The cells were then investigated by various cell and molecular biology techniques.
Results
Following treatment with antioxidant vitamins for 1 hour, a population of growth-arrested tumour cells and a population of dying ones were found. The cells died mostly by the mechanism of autoschizis. Hydrogen peroxide was found to be involved in this process, and it involved an increase in intracellular calcium. The increase in calcium in turn activated a DNA-degrading enzyme, and the DNA of the cells decreased thus leading to their death.
Conclusion
Vitamins C and K3 are able to induce cell death of human bladder tumour cells in vitro by activating a DNA-degrading enzyme.
References
Jamison JM, Gilloteaux J, Nassiri MR, Venugopal M, Neal DR, Summers JL. Cell cycle arrest and autoschizis in a human bladder carcinoma cell line following Vitamin C and Vitamin K3 treatment Biochemical Pharmacology 67 (2): 337-351, Jan 15, 2004.
