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Research: JEDRYCHOWSKI and co-work
Listed in Issue 85
Abstract
JEDRYCHOWSKI and co-workers, Epidemiology and Proventive Medicine, Coll. Med. Jagellonian University, Cracow, Poland, describe the relationship between alcohol intake and the risk of colorectal cancer at low levels of micronutrient intake.
Background
The purpose of the study was to assess the relationship between alcohol consumption and simultaneous intake of micronutrients that may have a protective function against colorectal cancer.
Methodology
Hospital-based case control study in Cracow, Poland. 180 cases of colorectal cancer were compared to an equal number of age-matched controls . A food frequency questionnaire covering 148 food items was used to assess typical dietary patterns .
Results
A consistent inverse association was found between the risk of colorectal cancer and the intake of retinol, thiamine or antioxidant micronutrients such as vitamins C and E or carotene . Furthermore, alcohol intake was found to be an important risk factor for colorectal cancer in a dose-dependent manner . The combination of high consumption of alcohol with deficient intake of retinol, carotene, and vitamins C and E shows a noticeably higher risk of colorectal cancer .
Conclusion
The data support the assumption that high alcohol consumption in combination with low intake of micronutrient s increases considerably the risk of colorectal cancer.
References
Jedrychowski W, Steindorf K, Popiela T, Wahrendsorf J, Tobiasz AB, Kulig J, Penar A. Alcohol consumption and the risk of colorectal cancer at low levels of micronutriant intake. Medical Science Monitor 8(5): CR357-363, May 2002.
