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Research: JEONG and COLLEAGUES,
Listed in Issue 173
Abstract
JEONG and COLLEAGUES, Department of Obstetrics and Gynecology, Kyung Hee University College of Medicine, Seoul, Korea investigated the relation between plasma carotenoids, retinol and tocopherol levels and ovarian cancer risk in Korean women.
Background
Methodology
Design: Hospital-based case-control study within six tertiary medical institutes in Korea. Population: Forty-five epithelial ovarian cancers and 135 age-matched controls. Preoperative plasma concentrations of beta-carotene, lycopene, zeaxanthin plus lutein, retinol, alpha-tocopherol, and gamma-tocopherol were measured by reverse-phase, gradient high-pressure liquid chromatography. Odds ratios (OR) and 95% confidence intervals (95%CI) were estimated by tertiles to evaluate the effect of micronutrients on endometrial cancer risk after adjustment for body mass (BMI) index, menopause, parity, oral contraceptive use, smoking status, and alcohol consumption status.
Results
Women in the highest tertile for beta-carotene had 0.12-times the risk of ovarian cancer of in the lowest tertile (OR 0.12; 95%CI 0.04-0.36). Women with the highest tertiles of lycopene (OR 0.09; 95%CI 0.03-0.32), zeaxanthin/lutein (OR 0.21; 95%CI 0.09-0.52), retinol (OR 0.45; 95%CI 0.21-0.98), alpha-tocopherol (OR 0.23; 95%CI 0.10-0.53) and gamma-tocopherol (OR 0.28; 95%CI 0.11-0.70) had lower risk of ovarian cancer than women in the lowest tertiles. Results were consistent across strata of socio-epidemiologic factors.
Conclusion
Micronutrients, specifically ss-carotene, lycopene, zeaxanthin, lutein, retinol, alpha-tocopherol, and gamma-tocopherol, may play a role in reducing the risk of ovarian cancer.
References
Jeong NH, Song ES, Lee JM, Lee KB, Kim MK, Cheon JE, Lee JK, Son SK, Lee JP, Kim JH, Hur SY and Kwon YI. Plasma carotenoids, retinol and tocopherol levels and the risk of ovarian cancer. Acta Obstetricia et Gynecologica Scandinavica. 88(4): 457-62. 2009. Comment in: Acta Obstet Gynecol Scand. 88(4):371-2; PMID: 19330571]. 2009.
