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Research: KALEESWARAN and COLLEAGUES,
Listed in Issue 184
Abstract
KALEESWARAN and COLLEAGUES, Department of Veterinary Pharmacology and Toxicology, Madras Veterinary College, Vepery, Chennai 600007, India tested the flavonoid Silyburn marianum for its antimutagenic activity, using the in vitro test the Ames bacterial reverse mutation assay.
Background
Silymarin, a polyphenolic flavonoid isolated from milk thistle (Silybum marianum), is being used clinically in Europe and Asia for the treatment of liver diseases. Silymarin has a strong antioxidative action capable of scavenging both free radicals and reactive oxygen species responsible for cancer.
Methodology
Silymarin, a powerful hepatoprotective and antioxidant, was chosen in the present study and was tested for its antimutagenic activity using an in vitro test, the Ames bacterial reverse mutation assay.
Results
The results indicated that silymarin showed a significant mutagenicity in frame shift mutant strains (TA97a and TA98) with metabolic activation. This compound also showed stronger antimutagenic effect against 2-aminofluorene and 4-nitroquinoline N-oxide induced mutation. When pre-, co- and post-treatment of silymarin was carried out, it showed stronger antimutagenic activity in the post-treatment with 2-aminofluorene and 4-nitroquinoline N-oxide in TA97a and TA98 strains.
Conclusion
References
Kaleeswaran S, Sriram P, Prabhu D, Chinnathambi, Vijayakumar and Mathuram LN. Anti- and pro-mutagenic effects of silymarin in the Ames bacterial reverse mutation assay. Phytotherapy Research. 23(10):1378-84. Oct 2009.
