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Research: KIDD USA writes
Listed in Issue 46
Abstract
KIDD USA writes that dementias and other severe cognitive dysfunction states pose a daunting challenge to existing medical management strategies and that an early intervention, integrative approach would seem to be appropriate. Nutrition and botanical therapies have proven degrees of efficacy and provide favourable benefit-to-risk profiles .
Background
Methodology
Results
and Discussion: The author reviews (103 references) 5 nutritional therapies: phosphatidylserine (PS), acetyl-1-carnitine (ALC), vinpocetine, Ginkgo biloba extract (GbE) and Bacopa monniera (Bacopa) . PS is a phospholipid enriched in the brain and which has been validated with double-blind trials for improvements of memory, learning, concentration, word recall and mood in middle-aged and elderly people suffering from dementia or age-related cognitive decline. PS has an excellent benefit-to-risk profile. ALC is an energiser and metabolic cofactor also benefiting various cognitive functions in the middle-aged and elderly, with a slightly less favourable benefit-to-risk profile. Vinpocetine, found in the lesser periwinkle Vinca minor is an excellent vasodilator and cerebral metabolic enhancer which has proven benefits for vascular-based cognitive dysfunction. The best preparations of GbE offer limited benefits for vascular insufficiencies and even more limited benefits for Alzheimers; "commodity" GbE products offer little, if any benefits at all. GbE and probably also vinpocetine are incompatible with blood-thinning drugs. Bacopa is an Ayurvedic botanical with apparent anti-anxiety, anti-fatigue and memory-strengthening effects.
Conclusion
The 5 nutritional/botanical substances contribute to a personalised approach for restoring cognitive function, perhaps eventually in conjunction with appropriate application of growth factors.
References
Kidd PM A review of nutrients and botanicals in the integrative management of cognitive dysfunction. Alternative Medicine Review 4(3): 144-61 Jun 1999.
