Research: KIM and MILNE

Listed in Issue 84

Abstract

KIM and MILNER, Nutritional Science Research Group, Division of Cancer Prevention, National Cancer Institute, Rockville, MD 20892, USA, reviewed (66 references) the molecular targets for Selenium in cancer prevention .

Background

Selenium has anticarcinogenic and antitumourogenic properties, as revealed by mounting evidence . Unfortunately, the amounts needed to bring about these effects in humans remain elusive .

Methodology

Results

If there is a positive response to exaggerated selenium intakes, it will likely depend on a variety of factors such as consumption of other dietary constituents and variation in a host of genetic pathways involved with cancer . Several biological mechanisms are probably involved including depressed carcinogen bioactivation, reduced cell proliferation, and increased apoptosis .

Conclusion

References

Kim YS, Milner J. Molecular targets for selenium in cancer prevention. Nutrition and Cancer 40 (1): 50-54, 2001.

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