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Research: KISHIMOTO and colleagues,
Listed in Issue 33
Abstract
KISHIMOTO and colleagues, School of Life Environmental Science, Mukogawa Womens University, Nishinomiya, Hyogo, Japan conducted a study, in mice, regarding the effectiveness of vitamin E in the prevention of lung cancer.
Background
Methodology
NNK (4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone was the chemical agent used to induce lung tumours.
Results
High doses of vitamin E suppressed NNK-induced increased activity of ornithine decarboxylase, a key enzyme of polyamine biosynthesis, in the lungs of mice 4 weeks following injection. Vitamin E, in contrast, increased the NNK-induced decrease of spermidine/spermine N1-acetyltransferase activity, a key enzyme of polyamine biodegradation. Vitamin E treatment suppressed NNK-increased levels of proliferating nuclear cell antigen, a marker of cell proliferation, and high doses of vitamin E suppressed NNK-induced lung tumourigenesis.
Conclusion
Vitamin E inhibits development of lung tumours in mice treated with NNK. The mechanism of inhibition is in part due to the regulation of polyamine metabolism.
References
Kishimoto M et al. The inhibitory effect of vitamin E on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in mice based on the regulation of polyamine metabolism. Cancer Lett 126(2): 173-8. Apr 24 1998.
Comment
Considering the fairly grim mortality statistics for lung cancer (about 2%) for 5- year survival, advances in understanding about how vitamin E can suppress cell proliferation and lung tumourigenesis is good news.
