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Research: KREIJKAMP-KASPERS
Listed in Issue 114
Abstract
KREIJKAMP-KASPERS and co-authors, The Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Netherlands, report on a trial of the effects of soy isoflavones on blood circulation in postmenopausal women.
Background
The incidence of cardiovascular disease in women increases after menopause, and this is thought to be related to the decrease in oestrogen. The aim of this study was to investigate whether soy protein, a rich source of the oestrogen-like isoflavones, could improve vascular function and thus potentially reduce the risk of cardiovascular disease.
Methodology
In this double-blinded randomized controlled study, 202 postmenopausal women were given either soy protein containing a daily dose of 99 mg of isoflavones (treatment) or milk protein (placebo) for one year. Blood pressure and endothelial function were measured at baseline and after the intervention period.
Results
Changes in endothelial function were not significantly different in both groups of women after the intervention. Blood pressure increased slightly but significantly more in the treatment group than in the placebo group during the study time. In a subset of the treatment group, blood pressure and endothelial function improved significantly.
Conclusion
The results of this trial do not support the hypothesis that soy isoflavones improve vascular function in postmenopausal women. However it remains to be tested whether certain subgroups of women may experience significant benefits.
References
Kreijkamp-Kaspers S, Kok L, Bots ML, Grobbee DE, Lampe JW, van der Schouw YT. Randomized controlled trial of the effects of soy protein containing isoflavones on vascular function in postmenopausal women. American Journal of Clinical Nutrition. 81 (1): 189-195, Jan 2005.
