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Research: KUCERA and colleagues,
Listed in Issue 47
Abstract
KUCERA and colleagues, Revmatologicka ordinace nemocnice MUDr. Mulace, Plzen studied the role of free radicals in the pathogenesis of inflammatory and degenerative diseases .
Background
Methodology
and Results: The results of the authors work provides evidence that the breakdown in superoxide is inadequate in inflammatory and degenerative diseases . This oxygen radical and its metabolites play a significant role in the pathogenesis of these diseases. In particular, a severe defect in superoxide degeneration was discovered in articular exudates of patients with active synovitis (inflammation of the synovial membrane). Administration of a preparation containing selenium, zinc, beta-carotene, vitamins C and E, as well as antirheumatic treatment improved the breakdown of superoxide and its metabolites and improved the patients prognosis. The long-term administration of the preparation produced even better results.
Results
Conclusion
References
Kucera M et al. Significance of free radicals in the pathogenesis of rheumatic diseases and possibilities of decreasing their pathogenic effects. Vnitrni Lekarstvi 44(12): 702-6. Dec 1998.
Comment
It is such a pity that merely an English language abstract is available for the above paper, as there remain so many unanswered questions, particularly what sort of antirheumatic treatment was used in conjunction with the antioxidant supplements.
