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Research: LOPEZ-SAEZ and co-workers,
Listed in Issue 91
Abstract
LOPEZ-SAEZ and co-workers, Department of Medicien, University of Cadiz School of Medicine, c/Dr. Maranon 6, E-11002 Cadiz, Spain, juanbosco.lopez@uca.es, have studied selenium and breast cancer.
Background
Controversy surrounds the relationship between low serum levels of selenium and reduced activity of selenium-dependent enzymes (such as glutathione peroxidase) and an increased risk of breast cancer.
Methodology
In this case-control study, the serum concentrations of selenium were compared in 200 women with breast cancer, 100 healthy women, and 100 women with chronic diseases.
Results
Mean serum concentrations of selenium in women with breast cancer were 81.1 micrograms/litre, and in women with other diseases they were 98.5 micrograms/litre (p = 0.0001).
Conclusion
Alterations in selenium concentrations in women with breast cancer appear to be a consequence of the disease rather than a cause. Very low selenium status could be due to the nature of cancer.
References
Lopez-Saez JB, Senra-Varela A, Pousa-Estavez L. Selenium in breast cancer. Oncology 64 (3): 227-231, 2003.
