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Research: MALILA and colleagues,
Listed in Issue 85
Abstract
MALILA and colleagues, National Public Health Institute, Department of Epidemiology and Health Promotion, Helsinki, Finland, nea.malila@cancer.fi, investigate dietary and serum alpha-tocopherol, beta-carotene, retinol, and the risk of colorectal cancer in male smokers.
Background
The objective was to study the association between dietary and serum antioxidant vitamins and the risk of colorectal cancer in smoking men .
Methodology
A prospective cohort study within a randomized placebo-controlled trial testing supplementation with alpha -tocopherol (50 mg/day), beta-carotene (20 mg/day) or both for their cancer prevention effects . 26,951 middle-aged male smokers took part in a cancer prevention trial with complete dietary and serum data available. Out of these, 184 were diagnosed with colorectal cancer during the 8 year follow-up . Relative risks were calculated with Cox proportional hazards models adjusting for trial supplementation, age, body mass index, serum cholesterol, cigarettes smoked per day, and physical activity.
Results
There was no significant association between dietary vitamin C or E, alpha- or gamma-tocopherol, retinol, alpha- or beta-carotene, lycopene or lutein + zeaxanthin and the risk of colorectal cancer . Serum alpha-tocopherol, beta-carotene, or retinol was also not associated with colorectal cancer risk.
Conclusion
These data support the results from previous studies in which no association between dietary antioxidant vitamins and carotenoids and the risk of colorectal cancer was found.
References
Malia N, Virtamo J, Virtanen M, Pietinen P, Albanes D, Teppo L. Dietary and serum alpha- tocopherol, beta-carotene and retinol, and risk for colorectal cancer in male smokers. European Journal of Clinical Nutrition 56 (7): 615-621, Jul 2002.
