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Research: MANNING and COLLEAGUES,
Listed in Issue 216
Abstract
MANNING and COLLEAGUES, Department of Chemistry, Susquehanna University, 514 University Avenue, Selinsgrove, PA 17870, USA evaluated acylphloroglucinol and xanthones for cytotoxicity using three human colon cancer cell lines cell lines and a normal human colon cell line.
Background
Methodology
An acylphloroglucinol, elliptophenone A, and two xanthones, elliptoxanthone A and elliptoxanthone B, were isolated from the aerial portions of Hypericum ellipticum together with three known xanthones, 1,3,7-trihydroxy-8-(3-methyl-2-butenyl)-9H-xanthen-9-one, 1,6-dihydroxy-4-methoxy-9H-xanthen-9-one, and 1,4,5-trihydroxy-9H-xanthen-9-one.
Results
Their structures were determined by spectroscopic analyses. The acylphloroglucinol and xanthones were evaluated for cytotoxicity using three human colon cancer cell lines cell lines (HT-29, HCT-116 and Caco-2) and a normal human colon cell line (CCD-18Co).
Conclusion
References
Manning K, Petrunak E, Lebo M, Gonzalez-Sarrias A, Seeram NP and Henry GE. Acylphloroglucinol and xanthones from Hypericum ellipticum. Phytochemistry. 72(7):662-7. May 2011.
