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Research: MAOKA and colleagues,
Listed in Issue 73
Abstract
MAOKA and colleagues, Research Institute for Production Development, 15 Shimogamo-Morimoto-cho, Sakyo-ku, 606-0805, Kyoto, Japan, maoka@mbox.kyoto-inet.or.jp, analysed anticarcinogenic activities of carotenoids isolated from the red pepper Capsicum annuum L.
Background
Methodology
Results
Capsanthin and related carotenoids isolated from the fruits of red paprika Capsicum annuum L. showed potent in vitro antitumour-promoting activity, with inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by the tumour promoter 12-O-tetradecanoylphorbol-13-acetate (TPA). Among them, capsanthin diester and capsorbin diester showed strong inhibitory effects. Furthermore, capsanthin, capsanthin 3'-ester and capsanthin 3,3'-diester, major carotenoids in paprika, exhibited potent antitumour-promoting activity in an in vivo mouse skin two-stage carcinogenesis assay using 7,12-dimethylbenz(a)anthracene as an inhibitor and TPA as a promoter.
Conclusion
References
Maoka T et al. Cancer chemopreventive activity of carotenoids in the fruits of red paprika Capsicum annuum L. Cancer Letters 172 (2): 103-9. Oct 2001.
