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Research: MAY, Department of Med
Listed in Issue 62
Abstract
MAY, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232-6303, USA. james.may@mcmail.vanderbilt.edu reviewed (117 references) the mechanisms by which ascorbic acid (vitamin C) may preserve nitric oxide (NO) and prevent endothelial dysfunction .
Background
Endothelial dysfunction in human coronary and peripheral arteries occurs in atherosclerosis, hypertension and other conditions, and manifests as a loss of endothelial-dependent vasodilation . The dysfunction is typically associated with decreased production of NO by the endothelium. Vitamin C improves the endothelial-dependent vasodilation present in the clinical conditions. Its mechanism of action in this respect in unknown but may involve preservation or increased production of NO.
Methodology
Results
Conclusion
Use of ascorbic acid supplements in human diseases is supported by the ability of such supplements to enhance defective endothelial function. However, we need to determine which particular mechanisms account for the effect and ensure that there are no toxic side effects.
References
May JM. How does ascorbic acid prevent endothelial dysfunction? Free Radical Biology & Medicine 28 (9): 1421-9. May 2000.
