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Research: MCCULLOCH and colleagues,
Listed in Issue 85
Abstract
MCCULLOCH and colleagues, Pine Street Clinic, San Anselmo, CA, USA, analyze Chinese herbal medicine and interferon in the treatment of chronic hepatitis B.
Background
This meta-analysis was performed in order to evaluate the effectiveness of Chinese herbal medicine alone or in combination with interferon-alpha in treating chronic hepatitis B .
Methodology
TCMLARS, AMED, CISCOM, EMBASE, MEDLINE,and Cochrane Collaboration databases were searched and the articles' bibliographies were handsearched .
Results
Chinese herbal medicine significantly reduced sero-reversion of HbsAg and was equivalent to interferon-alpha in sero-reversion of HbeAg and Hepatitis B virus DNA . Chinese herbal medicine combined with interferon-alpha significantly increased seor-reversion of HBsAg, HBeAg, and viral DNA . The Chinese herb active component bufotoxin combined with Interferon-alpha significantly increased HbeAg and viral DNA sero-reversion . The Chinese herb active component kurorinone was equivalent to interferon-alpha in sero-reversion of HbeAg and viral DNA .
Conclusion
Although the quality of existing studies is poor, the data nevertheless suggest that further studies of Chinese herbal medicine and interferon in chronic hepatitis B infection are justified .
References
McCulloch M, Broffman M, Gao J, Colford JMJr. Chinese herbal medicine and interferon in the treatment of chronic hepatitis B: a meta-analysis of randomized. controlled trials. American Journal of Public Health 91 (10): 1619-1628, Oct 2002.
