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Research: MDCAFFERY and COLLEAGUES,
Listed in Issue 178
Abstract
MDCAFFERY and COLLEAGUES, Weight Control and Diabetes Research Center, Brown Medical School, Providence, RI 02903, USA. jeanne_mccaffery@brown.edu evaluated whether genes related to inflammation, blood cell parameters and omega-3 fatty acid metabolism could be predictors of depression in patients with heart disease.
Background
Numerous studies suggest that the prevalence of depression is greater among cardiac patients than in the general population. However, little attention has been paid to the possibility of genetic contributions to depressive symptoms in cardiac patients.
Methodology
We conducted a candidate gene study focusing on genes related to inflammation, platelet aggregation, endothelial function and omega-3 fatty acid metabolism as predictors of depressive symptoms among 977 participants with established cardiovascular disease.
Results
Results suggested that genetic variation related to endothelial dysfunction is predictive of depressive symptoms and that endothelial dysfunction may be a novel mechanism contributing to depressive symptoms among cardiac patients.
Conclusion
References
McCaffery JM, Duan QL, Frasure-Smith N, Barhdadi A, Lesperance F, Theroux P, Rouleau GA and Dube MP. Genetic predictors of depressive symptoms in cardiac patients. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics: the Official Publication of the International Society of Psychiatric Genetics. 150B(3): 381-8. Apr 5 2009. NLM. NIHMS64454 [Available on 04/05/10]; NLM. PMC2660383 [Available on 04/05/10]. (c) 2008 Wiley-Liss, Inc.
