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Research: MEUILLET and colleagues,
Listed in Issue 102
Abstract
MEUILLET and colleagues, Department of Molecular and Cellular Biology, Arizona Cancer Center, The University of Arizona College of Medicine, Tucson, Arizona 85724, USA, mnelson@zacc.arizona.edu, have reviewed (111 references) the chemoprevention of prostate cancer with selenium. Abstract: Prostate cancer is the most commonly diagnosed cancer in men in the USA, and the second leading cause of cancer-related deaths. Its primary causes are not known, and it is therefore not possible to develop primary prevention strategies. However secondary intervention strategies involving selenium and other nutritional agents represent a promising alternative to reduce both the occurrence and the mortality of prostate cancer. The article discusses ongoing clinical trials, and also preclinical studies that provide insight into the biochemical and molecular mechanisms that underlie the anti-carcinogenic activity of selenium.
Background
Methodology
Results
Conclusion
References
Meuillet E, Stratton S, Prasad CD, Goulet AC, Kagey J, Porterfield B, Nelson MA. Chemoprevention of prostate cancer with selenium: an update on current clinical trials and preclinical findings. Journal of Cellular Biochemistry 91 (3): 443-458, Feb15, 2004.
