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Research: MEYDANI and colleagues,
Listed in Issue 33
Abstract
MEYDANI and colleagues, Nutritional Immunology Laboratory Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111 USA review (71 references) the effects of antioxidants upon cytokines and immune functions in the aged.
Background
Methodology
Results
and Conclusions: The authors write that oxidant/antioxidant balance is an important determinant of immune cell function, in maintaining the integrity and functionality of membrane lipids, cellular proteins, nucleic acids and controlling signal transduction and gene expression in immune cells. Optimal antioxidants levels are required to maintain the immune response for all age groups; however this requirement may be even more critical in the aged, where age-associated dysregulation of immune response is well-documented, particularly of cytokine production and T-cell-mediated function. The review summarises animal and human studies regarding the effect of antioxidants, vitamin E, beta-carotene and glutathione upon cytokine production and T-cell-mediated function in the aged.
Conclusion
References
Meydani SN et al. Antioxidant modulation of cytokines and their biologic function in the aged. Z Ernahrungswiss 37(Suppl 1): 35-42. 1998.
