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Research: MIZUNO, Division of Li
Listed in Issue 66
Abstract
MIZUNO, Division of Life Science, Graduate School of Science and Technology, Kobe University, Japan investigated the changes in the contents of antitumour polysaccharides from the mushrooms Lentinus edodes (lentinan) and Grifolafrondosa (GGF) during storage .
Background
Methodology
An ELISA inhibition assay was used to measure the changes in contents of the study substances.
Results
The contents of antitumour polysaccharides of mushrooms stored at low temperature showed hardly any changes, whereas their contents decreased markedly at higher temperatures (20°C). Since lentinan is believed to increase the antitumour activity of macrophages, the effects of the extract from Lentinus edodes stored at different temperatures on tumour necrosis factor-alpha (TNF-alpha) and nitric oxide (NO) were investigated. Few differences were found on the productions of TNF-alpha and NO by Lentinus edodes stored at low temperature and fresh mushrooms. However, there was a significant decrease in cytokine production in Lentinus edodes stored at 20 °C .
Conclusion
The results indicate that low-temperature storage is more effective in maintaining the quality of mushrooms and their contents of antitumour polysaccharides as health-beneficent foods.
References
Mizuno M. Anti-tumor polysaccharides from mushrooms during storage. BioFactors 12 (1-4): 275-81. 2000.
