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Research: MURRAY and coworkers,
Listed in Issue 82
Abstract
MURRAY and coworkers, Sealy Center for Cancer Cell Biology, University of Texas Medical Branch, Galveston, Texas 77555-1048, USA, further evaluated the role of the enzyme protein kinase C beta-II in colon carcinogenesis .
Background
These researchers have previously shown that colonic protein kinase C beta-II is induced during colon carcinogenesis in humans and rodents, and that elevated levels of the enzyme in transgenic mice enhanced colon carcinogenesis.
Methodology
Investigation of transgenic mice as animal model.
Results
It was shown that dietary omega-3 fatty acids inhibit colonic protein kinase C beta-II and block the associated enhanced carcinogenesis .
Conclusion
These data indicate that dietary omega-3 fatty acids prevent colon cancer, at least in part, through inhibition of protein kinase C beta-II signalling pathways.
References
Murray NR et al. Protein kinase C betaII and TGFbetaRII in omega-3 fatty acid-mediated inhibition of colon carcinogenesis. The Journal of Cell Biology 157 (6): 915-20. Jun 2002.
