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Research: MYUNG and COLLEAGUES,
Listed in Issue 191
Abstract
MYUNG and COLLEAGUES, Korean Meta-analysis (KORMA) Study Group, Cancer Epidemiology Branch, Research Institute, Smoking Cessation Clinic and Center for Cancer Prevention and Detection, Hospital, National Cancer Center, Goyang, Korea investigated quantitative effects of vitamin or antioxidant intake on cervical neoplasm using meta-analysis.
Background
Case-control studies have reported the preventive effect of vitamin or antioxidant intake on cervical neoplasms such as cervical intraepithelial neoplasia (CIN) and invasive cervical cancer. However, the findings are inconsistent.
Methodology
The authors searched PubMed, EMBASE and the Cochrane Library in November 2008. All articles searched were independently reviewed and selected by two evaluators according to predetermined selection criteria. Selection Criteria: The authors included case-control studies reporting an association between vitamin or antioxidant intake (or serum level) and cervical neoplasm risk and reporting the adjusted odds ratios (OR) and 95% confidence intervals (CI), whenever possible. Data Collection And Analysis: After retrieval of data from selected articles, we performed a meta-analysis using both fixed-effects and random- effects models.
Results
Of 274 articles meeting our initial criteria, the authors included 22 case-control studies involving a total of 10,073 participants. In meta-analyses by type of vitamin or antioxidant, a significant preventive effect on cervical neoplasm was found in intakes of vitamin B12 (OR 0.35, 95% CI 0.19-0.63; n=2), vitamin C (OR 0.67, 95% CI 0.55-0.82; n=8), vitamin E (OR 0.56, 95% CI 0.35-0.88; n=10), and beta-carotene (OR 0.68, 95% CI 0.55-0.84; n=9).
Conclusion
The findings of this meta-analysis indicate that overall, there were preventive effects of vitamin or antioxidant intake on cervical neoplasms in case-control studies.
References
Myung SK, Ju W, Kim SC and Kim H. Vitamin or antioxidant intake (or serum level) and risk of cervical neoplasm: a meta-analysis. [Review] BJOG: An International Journal of Obstetrics & Gynaecology. 118(11): 1285-91, 2011.
Comment
The above research studies demonstrate that alpha- and gamma-tocopherol serum concentrations were associated with reduced risks of aggressive prostate cancer, and that vitamin or antioxidants were preventive against cervical cancer. It is imperative that such research be followed up with further clinical treatment data and studies.
