Positive Health Online
Your Country
![[Image: http://www.abundanceandhealth.co.uk]](/img/original/BannerAvatar/2836.df7d2315253110ff5b3a566f94871f99.jpg "http://www.abundanceandhealth.co.uk")
![[Image: http://www.balens.co.uk]](/img/original/BannerAvatar/2148.50367fa908013fae0a7f1a171543ef92.jpg "http://www.balens.co.uk")
![[Image: https://www.water-for-health.co.uk/]](/img/original/BannerAvatar/4046.12831f50177f8848ee87b8e94411d6b3.jpg "https://www.water-for-health.co.uk/")
![[Image: http://www.drsgoodman.com/books-goodman/52-nutrition-and-cancer]](/img/original/BannerAvatar/1859.1296090fd8385e7ceff51c8011559097.jpg "http://www.drsgoodman.com/books-goodman/52-nutrition-and-cancer")
Research: NI and co-workers,
Listed in Issue 151
Abstract
NI and co-workers, Department of Urology and Pathology, University of Rochester, Rochester, New York 14642, USA, have elucidated a reason for the differences in sensitivity to vitamin E found in different prostate tumours.
Background
Epidemiological studies showed Vitamin E has protective effects against prostate cancer. Interestingly, different prostate cancer cells have different sensitivity to Vitamin E. The aim of this study was to determine whether cellular Vitamin E bioavailability and its transport proteins are important contributing factors.
Methodology
In this in vitro study using cells in culture, vitamin E (alpha-tocopherol) was used to treat prostate cancer LNCaP, PC3, and DU145 cells, and their growth rates were examined. Cellular levels of Vitamin E were quantified as the index of bioavailability. The expression levels of Vitamin E transport proteins were determined.
Results
Among these prostate cancer cells, the cell lines LNCaP and PC3 cells were sensitive to vitamin E treatment. Cellular levels of Vitamin E positively correlated with their inhibitory effects. Further study found expression levels of Vitamin E transport proteins, including tocopherol associated protein, scavenger receptor class B type I, alpha-tocopherol transfer protein, and ATP binding cassette transporter A1, were different in various PCa cells, which may contribute to cellular Vitamin E bioavailability. This notion is further supported by the findings that overexpression or knockdown of TTP could alter cellular Vitamin E levels in PCa cells.
Conclusion
Growth-inhibiting efficacy of Vitamin E is correlated with its cellular bioavailability in PCa cells. Modulating the expression of the efflux or influx transporters could sensitize the growth inhibition efficacy of Vitamin E in prostate cancer cells.
References
Ni J, Pang ST, Yeh S. Differential retention of alpha-vitamin E is correlated with its transporter gene expression and growth inhibition efficacy in prostate cancer cells. Prostate 67 (5): 463-471, Apr 1, 2007.
