Positive Health Online
Your Country
![[Image: http://www.abundanceandhealth.co.uk]](/img/original/BannerAvatar/2836.df7d2315253110ff5b3a566f94871f99.jpg "http://www.abundanceandhealth.co.uk")
![[Image: https://www.water-for-health.co.uk/]](/img/original/BannerAvatar/4046.12831f50177f8848ee87b8e94411d6b3.jpg "https://www.water-for-health.co.uk/")
![[Image: http://www.balens.co.uk]](/img/original/BannerAvatar/2148.50367fa908013fae0a7f1a171543ef92.jpg "http://www.balens.co.uk")
![[Image: http://www.drsgoodman.com/books-goodman/52-nutrition-and-cancer]](/img/original/BannerAvatar/1859.1296090fd8385e7ceff51c8011559097.jpg "http://www.drsgoodman.com/books-goodman/52-nutrition-and-cancer")
Research: O’BYRNE and others,
Listed in Issue 87
Abstract
O’BYRNE and others, Center for Human Nutrition and the Division of Clinical Biochemistry and Human Metabolism, Department of Pathology, University of Texas Southwestern Medical Center, Dallas USA, compared the antioxidant effects of Concord grape juice flavonoids with alpha-tocopherol on markers of oxidative stress in healthy adults.
Background
Concord grape juice is a rich source of flavonoids, which have been shown to have greater antioxidant activity than alpha-tocopherol (a form of vitamin E) in vitro. However the activities have not been compared in vivo.
Methodology
32 subjects were randomly assigned to receive either 400 IU of alpha-tocopherol per day (17 subjects) or 10 ml of Concord grape juice per kilogram of body weight per day (15 subjects) for two weeks. Serum oxygen radical absorbance capacity, plasma protein carbonyls, urinary isoprostanes, and resistance of LDL to oxidation were measured before and after that time.
Results
After supplementation, plasma alpha-tocopherol increased by 92% in subjects who had received this supplement, and plasma total and conjugated phenols increased 17% and 22% in subjects who had received grape juice. Concord grape juice was associated with significantly higher triacylglycerols than alpha-tocopherol. Both supplements increased serum oxygen radical absorbance capacity significantly, and LDL oxidation rate was significantly decreased, with no difference in effectiveness. Protein carbonyl concentration decreased 20% after grape juice supplementation, which was a significantly different response to that after alpha-tocopherol supplementation.
Conclusion
In healthy adults, 10 ml of Concord grape juice per kg of body weight per day increased serum antioxidantcapacity and protected LDL against oxidation to an extent similar to that obtained with 400 IU of alpha-tocopherol, but decreased native plasma protein oxidation significantly more than alpha-tocopherol. Concord grape juice flavonoids are potent antioxidants that may protect against oxidative stress and reduce the risk of free radical damage and chronic disease.
References
O’Byrne DJ, Devaraj S, Grundy SM, Jialal I. Comparison of the antioxidant effects of Concord grape juice flavonoids and alpha-tocopherol on markers of oxidative stress in healthy adults. The American Journal of Clinical Nutrition 76 (6): 1367-1374, Dec 2002.
