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Research: OGASAWARA and others,
Listed in Issue 148
Abstract
OGASAWARA and others, Toyama Prefectural Institute for Pharmaceutical Research, Imizu, Japan, masaru.ogasawara@pref.toyama.lg.jp, have elucidated the effects of different antioxidants on the metastasis, invasiveness and growth of colon cancer cells.
Background
The aim of this study was to compare 20 antioxidants including antioxidative vitamins and polyphenols in terms of their inhibitory activities against the in vitro invasion, growth and experimental lung metastasis of murine colon 26-L5 carcinoma cells.
Methodology
In vitro study using mouse colon cancer cells in culture.
Results
Among the compounds tested, epigallocatechin gallate (EGCG), gallocatechin gallate and genistein exhibited significant reductions at 77%, 46% and 44% in tumour metastasis by intraperitoneal administration for 5 day beginning at 3 days before tumour inoculation, respectively. Quercetin also showed a slight but not statistically significant inhibition. Alpha-tocopherol, beta-carotene, ascorbic acid, epicatechin gallate and epigallocatechin had no effect. EGCG also inhibited tumour metastasis in a dose-dependentfashion with 98% suppression at 2 micromol. EGCG significantly inhibited tumour cell invasion and proliferation, but its inhibition of these activities was much less effective than that of other compounds which did not show any antimetastatic effect. No statistically significant relationship was observed between the radical scavenging activities of the test compounds and their rates of inhibition of tumour metastasis. The antimetastatic mechanism of EGCG thus seems to be independent of its inhibition of tumour invasion and growth, as well as its radical scavenging activity.
Conclusion
These results suggest that epigallocatechin gallate (a compound found in green tea) is potentially beneficial for tumour metastasis inhibition.
References
Ogasawara M, Matsunaga T, Suzuki H. Differential effects of antioxidants on the in vitro invasion, growth and lung metastasis of murine colon cancer cells. Biological & Pharmaceutical Bulletin 30 (1): 200-204, Jan 2007.
